Discipline
|
Integrated course
|
Denomination
|
Biochemistry of complex systems and Bioinformatics
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Biochemistry
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
Goals: To provide knowledge on biochemical and molecular mechanisms regulating the metabolic relationship between different organs and / or tissues. Contents: 1) Metabolism of calcium and phosphate Role of Vitamin D, parathyroid hormone and calcitonin in calcium and phosphate homeostasis. 2) Biochemistry of bones and teeth Role of osteoblasts and osteoclasts cells in bone mineralization and bone resorption Biochemical markers of bone metabolism. 3) Biochemistry of liver Detoxification and ethanol metabolism. 4) Biochemistry of kidneys Urine formation Filtration and reabsorption Renal metabolism Endocrine functions of the kidney. 5) Biochemistry of adipose tissue White and brown adipose tissue Thermogenesis. 6) Muscle biochemistry Structural organization Skeletal muscle cell contraction. 7) Biochemistry of cardiac muscle Substrate utilization in the myocardium Mechanism and Contraction Events of Cardiac Muscle Fibers. 8) Biochemistry of cancer-cell metabolism Warburg effect Role of Hypoxia-inducible factor 1 in cancer. 9) Biochemistry of the nervous system Brain metabolism Neurotransmitters synthesis. 10) Biochemistry of the sensory systems: vision, olfaction, taste, hearing and touch
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|
Module
|
Bioinformatics
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
Learning Objectives: Provide the students with tools for computational analysis of proteins and genomes. Contents: 1) Sequence alignment methods 2) Methods for studying protein families 3) Protein structure analysis by similarity search 4) Orphan proteins analysis 5) Search for coding regions in sequenced genomes 6) Search for other functional sequences 7) EST and gene expression analysis 8) Databases
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|
|
Discipline
|
Module
|
Denomination
|
Biochemistry
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Bioinformatics
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Microbiology and Microbial Biotechnology
|
Modules
|
2
|
CFU
|
8
|
This teaching course includes the following modules
Module
|
Microbial biotechnology
|
Credit
|
5
|
SDS
|
MED/07
|
Description
|
|
|
Module
|
Molecular and cellular Microbiology
|
Credit
|
3
|
SDS
|
MED/07
|
Description
|
Learning objectives: Study of the molecular and cellular mechanisms of host-parasite interactions involved in the pathogenesis of infectious diseases Study of the role of microorganisms in different biotechnological processes and analysis of the potential of genetically modified organisms or wild type as incubators for the production of goods and services applicable in the biomedical field Contents: 1) Cellular and molecular mechanisms of bacterial pathogenicity: entrance, adhesion, colonization, tissue invasion and permanence; evasion to the immune response; secretion systems; RTX Toxins and production of the damage. 2) Molecular processes of acute and chronic inflammatory response involved in the pathogenesis of infectious diseases The example of Mycobacterium tuberculosis. 3) Interactions between microbial communities: The bacterial biofilm, Molecular mechanisms of the biofilm formation in Gram-positive and negative bacteria. 4) Quorum sensing: Species-specific and multispecies bacterial interactions Cellular and molecular mechanisms involved in bacterial interactions and their involvement in the host response. 5) Microorganisms as a tool and as a product in biotechnology; the model systems in biotechnology microbial: Bacteria, Yeast and Viruses. 6) Tools of microbial biotechnology: Plasmids and viruses as cloning vectors Hosts for cloning Cloning and expression of heterologous genes. 7) Manipulation of Gene Expression in Prokaryotes: Gene expression from strong and regulatable promoters, Fusion proteins, Unidirectional tandem gene arrays, Translation expression vectors, Increasing protein stability, Protein folding, Overcoming oxygen limitation, DNA integration into the host chromosome, Increasing secretion, Metabolic load. 8) Production of microbial recombinant proteins: Escherichia coli and other bacteria such expression systems, approaches and strategies in the production of proteins of medical biotechnology. 9) Expression in eukaryotic systems: Saccharomyces cerevisiae, Pichia pastoris, others yeast systems, Baculovirus-Insect cells Description of vectors and promoters (constitutive and inducible) most commonly used; advantages and limitations of the expression systems. 10) Microbial production of protein therapeutics: pharmaceuticals, enzymes, recombinant antibodies, therapeutic agents against HIV. 11) Vaccines: Subunit vaccines (Herpes Simplex Virus, Cholera); Peptide vaccines (Malaria); Genetic immunization (DNA and RNA vaccines); Attenuated vaccines (Cholera, Salmonella species); Vector vaccines (vaccines directed against Bacteria and Viruses, bacteria as antigen delivery systems) New generation vaccines .
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|
|
Discipline
|
Module
|
Denomination
|
Microbial biotechnology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Molecular and cellular Microbiology
|
Modules
|
|
CFU
|
3
|
This teaching course includes the following modules
|
Discipline
|
One-module course
|
Denomination
|
Molecular and cellular Microbiology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Molecular and cellular Microbiology
|
Credit
|
5
|
SDS
|
MED/07
|
Description
|
|
|
|
Discipline
|
Integrated course
|
Denomination
|
Developmental Biology and control of gene expression
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Biology
|
Credit
|
5
|
SDS
|
BIO/13
|
Description
|
Learning objectives:
Students are expected to acquire knowledge and competence regarding the main molecular mechanisms that underlie development of multicellular organisms
Major focus will be on the main animal models used as tools in basic and biotecnological research
Contents:
1) Basic principles and modules in cell communication: Notch, Wnt, Hedgehog and TGFb based signaling pathways Endocytosis in signaling pathways regulation Signaling integration during development of multicellular organisms.
2) Universal mechanisms of animal development: basic animal body plan, transcriptional control, regulatory DNA, combinatorial control, cell memory, morphogens, inductive signal gradients, asymmetric cell division, sequential induction
3) Mechanisms of pattern formation in Drosophila melanogaster and amphibians.
4) Developmental timing, morphogenesis and growth. 5) Regeneration of the epithelial surface in the small intestine; fibroblasts and their transformations; the connective tissue family; the growth and remodelling of cartilage and bone; the growth and regeneration of blood vessels and endothelial cells; the bone marrow and the blood cells; scheme of haematopoiesis; genesis and regeneration of skeletal muscle. 6) Mouse: differentiation events before implantation, ES cells, transgenic mice generation
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|
Module
|
Molecular Biology
|
Credit
|
5
|
SDS
|
BIO/11
|
Description
|
Learning objectives: The aim is to provide knowledge about the technologies of gene expression and transfer in vitro and in vivo and of gene editing for medical applications in the fields of vaccination, passive immunotherapy and genetic dysfunction Understanding of some fundamental mechanisms regulating gene expression and in turn cell identity and fate. Contents: 1) Homologous recombination and recombineering Engineering of expression vectors by homologous recombination The mechanisms of homologous recombination in prokaryotes will be described with particular attention to those usable for biotechnological applications. 2) Genome editing in a dish and in vivo Use of zinc finger nucleases, Talen and CAS9/CRISP Description of the new technologies of genome editing using site-specific nucleases and their use to generate mutants and cell lines expressing therapeutic protein. 3) Genome editing applications focused to human therapy Applications of genome editing using site-specific nucleases for the therapy of genetic diseases. 4) Gene expression regulation in the determination of cell fate a) Transcription factors The function of master genes in the early phases of development B) microRNAs The fine regulation of gene expression at post-transcriptional level C) ceRNAs The recent discovery of post-transcriptional gene regulation.
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|
|
Discipline
|
Module
|
Denomination
|
Biology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Molecular Biology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Advanced diagnostics
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Molecular diagnostics
|
Credit
|
5
|
SDS
|
BIO/12
|
Description
|
Learning objectives: Knowledge of basic and advanced methodologies for the molecular analysis and for the identification of disease-associated genes Rationale of direct type genetic testing to detect disease-associated genetic variants; of indirect type genetic testing, to look at the segregation of a disease with genetic markers; of linkage analysis for identifying genome regions that are implicated in disease traits Interpretation of molecular results. Contents: 1 Introduction to molecular diagnostics. - Transmission mode and heterogeneity in genetic diseases. - Variable penetrance and expressivity Genotype-phenotype correlation. - Post-natal and prenatal diagnosis; genetic counseling. - Types of mutation Pathogenic mechanisms and validation of mutations. 2 Advanced methods for identifying genetic variants - Surveyor Nuclease, microarrays or DNA chips. - High-throughput DNA sequencing. - TP-PCR, MLPA, qPCR, CGH array. - Microsatellite instability. 3 Applied molecular diagnostics - Molecular diagnosis of monogenic inherited diseases. - Molecular diagnosis of genetically heterogeneous disorders. - Molecular diagnosis of triplet repeat disorders. - Molecular diagnosis of inherited cancers and hemolymphoproliferative diseases. - Molecular diagnosis of genomic imprinting-associated diseases. 4 Discussion of selected case studies and formal mode of reporting.
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|
Module
|
Laboratory Medicine methods
|
Credit
|
5
|
SDS
|
MED/46
|
Description
|
Learning objectives: Students are expected to develop the critical capacity for using the most advanced laboratory methods (in addition to traditional biochemical markers) in order to assess human organs and tissues functionality. Contents: 1) The specialized laboratory of Clinical Biochemistry - Decision analysis. - Evidence Based Approach. - Clinic interface. 2) Examples of clinical biochemistry and molecular biology diagnosis integration in the clinical evaluation of organs and systems. - Integrated laboratory evaluation of liver function - Integrated laboratory evaluation of exocrine pancreas function Hereditary pancreatitis. - Integrated laboratory evaluation of cardiac activity abnormalities; the laboratory role in the diagnosis and prevention of cardiovascular diseases. - Integrated laboratory evaluation of kidney function - Hemostasis and coagulation: integrated diagnostics of hemophilia - Integrated laboratory evaluation of recessive diseases: Cystic Fibrosis
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|
|
Discipline
|
Module
|
Denomination
|
Molecular diagnostics
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Laboratory Medicine methods
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
System Pharmacology and Cellular and Gene Therapy
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
System Pharmacology and pharmacogenetics
|
Credit
|
5
|
SDS
|
BIO/14
|
Description
|
Learning objectives: At the end of the course, students are expected to acquire knowledge and competence regarding the main classes of drugs for the treatment of human diseases In particular, major focus will be on the molecular targets of drug action, and on the genetic basis of the interindividual and interethnic variability in drug response. Contents: 1 Historical background, significance and clinical relevance of pharmacogenetis and pharmacogenomics for drug efficacy and toxicity prediction 2 Pharmacology and pharmacogenetics of drugs acting on the gastrointestinal system: agents for the control of gastric acidity and peptic ulcers, laxatives, antidiarrheal drugs, antiemetics and drugs against motion sickness 3 Pharmacology and pharmacogenetics of drugs acting on the endocrine system: oestrogens, progestins, hormonal contraceptives, corticosteroids. 4 Pharmacology and pharmacogenetics of drugs acting on the central nervous system: antipsychotics, antidepressants, hypnotics and sedatives, anticonvulsants, opioid analgesics, drugs for the treatment of neurodegenerative diseases (anti-Parkinson, anti-Alzheimer) Pharmacogenomics of the blood-brain barrier and drug resistance. 5 Pharmacology and pharmacogenetics of drug addiction (cocaine, MDMA, other psychostimulants). 6 Pharmacology and pharmacogenetics of drugs acting on the cardiovascular system: blood pressure lowering agents, diuretics, drugs against heart failure Genetic basis of drug-induced arrhythmias 7 Pharmacology and pharmacogenetics of lipid-lowering drugs. 8 Pharmacology and pharmacogenetics of antiasthmatics 9 Pharmacology and pharmacogenetics of antidiabetic drugs: insulin, oral hypoglycemics 10 Pharmacology and pharmacogenetics of anti-platelet drugs and anticoagulants. 11 Pharmacology and pharmacogenetics of antineoplastics.
|
|
Module
|
Cellular and Gene Therapy
|
Credit
|
5
|
SDS
|
BIO/12
|
Description
|
Learning objectives: The aim of the course is to provide students with knowledge and elements of critical discussion on the methodological approaches for gene and cell therapy as well as applications of these methods in both animal models and humans. Contents: 1) Overview of gene therapy - Definition of vectors and target cells; types of transgenes and applications; regulation of the expression; primary cell cultures; cell banking, and applications of flow cytometry and cell sorting; regulatory aspects of the production of drugs for gene and cell therapy. 2) non-viral vectors – naked plasmids; physical and chemical methods for DNA transfer and their applications; RNA interference and its main applications for therapeutic purposes. 3) adenoviral vectors - Types of adenoviral vectors; toxicity; applications in vaccine and gene therapy. 4) AAV Vectors – vector development; identification of serotypes for alternative tropism; main applications in therapy. 5) Retroviral and lentiviral vectors - Features carriers and differences; pseudotyping; methods of production also for clinical use. 6) stem cells - Definition; Embryonic stem cells; generation, use and applications in gene therapy; Stem cells from adult tissues; Stem cells from bone marrow and use in regenerative medicine; iPS cells and their applications. 7) Tissue regeneration - Identification and use of cells with osteoblastic potential and strategies to induce osteoblastic differentiation; regeneration of epidermis and cornea; identification and culture of stem cells for specific applications; biomaterials and their use in regenerative medicine. 8) Gene therapy of inherited diseases - Development and applications of gene therapy strategy for the treatment of metabolic diseases in humans; Gene therapy for congenital immunodeficiencies and applications in humans; genotoxicity and potential solutions. 9) Gene and regenerative therapy for common diseases - therapy of cardiovascular diseases and regeneration of cardiac tissue; development of medical devices for gene transfer; regeneration of myocardial tissue by reprogramming; therapeutic angiogenesis; gene and cell therapy of diabetes mellitus. 10) Gene therapy from bench to bedside: study of the development of gene therapy drugs from the evaluation of the metabolic disease to the marketing of the drug for gene therapy.
|
|
|
Discipline
|
Module
|
Denomination
|
System Pharmacology and pharmacogenetics
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Cellular and Gene Therapy
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Genetics and molecular pathology
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Medical genetics
|
Credit
|
5
|
SDS
|
MED/03
|
Description
|
Learning Objectives: Students are expected to understand the genetic bases of mendelian and complex diseases, analyzed by classic genetic approaches and by functional genomics. Contents: MONOGENIC AND MULTIFACTORIAL INHERITANCE - Mendelian inherited diseases Molecular bases of haemoglobinopathies Genetic counseling Complex traits and multifactorial inheritance Modifier genes and susceptibility genes. HUMAN GENOME ORGANIZATION AND VARIATION - Normal and pathogenic DNA variants The non-coding genome: structure and function of novel classes of small and long non-coding RNAs HUMAN GENE EXPRESSION - Chromatin conformation: DNA methylation and the histone code A comprehensive overview of transcription and its control: the ENCODE project Mosaicism and chimerism in humans Epigenetic memory and imprinting Molecular bases of X-inactivation and imprinting. GENOMEWIDE VIEW OF COMMON HUMAN DISEASES - Advanced approaches to the Identification of disease genes The genomics of cancer Tumor markers Therapeutic targets in cancer STUDYING HUMAN CHROMOSOMES - Classic cytogenetic analysis Molecular cytogenetics: FISH, chromosome painting, multicolor FISH, SKY, bandeggio multicolore, chromosome painting parziale regione-specifica, array CGH e CNV PRINCIPLES OF DEVELOPMENT - Early human development Cell specialization, pattern formation and morphogenesis Definition and classification of birth defects. EVOLUTIONARY GENETICS - Evolution of genes and traits Natural selection Molecular evolution and the neutral theory Evolutionary forces shaping human genome organization and function. POPULATION GENETICS - Factors affecting allele frequencies in human populations Using the Hardy-Weinberg relationship in genetic counseling DNA profiling and forensic genetics.
|
|
Module
|
Molecular pathology
|
Credit
|
5
|
SDS
|
MED/04
|
Description
|
Learning objectives: Knowledge of the basic processes underlying cardiovascular disease: myocardial ischemia, hypertension, cardiomyopathy, heart failure, lipid metabolism, atherosclerosis, Obesity, Metabolic syndrome.
Learning of the most advanced methods for the diagnosis and molecular therapy of these diseases Mechanisms of cell death: apoptosis, autophagy, entosis, necroptosis. Contents: 1) Mechanisms of cell death Necrosis, apoptosis, autophagy, entosis. 2) Lipid metabolism Lipoproteins, endogenous and exogenous metabolism. 3) Hyperlipidemias: classification, identification of major genetic defects underlying the most common forms Medical management based on the knowledge of the pathways of lipid biosynthesis. 4) Obesity: mechanisms regulating food introit Role of the hypothalamus Leptin, the Neuropeptide Y, the MSH Receptor Advantages of the study of animal models of obesity. 5) Pathophysiology of atherosclerosis Features of the blood vessel Cellular and molecular components involved in the formation of plaque The pathogenetic hypotheses of atherosclerosis Methods of invasive cardiology for the treatment of coronary lesions The coronary angioplasty, stents, drug-eluting stents. 6) The ischemic heart disease Definition Pathogenetic mechanisms Diagnosis Principles of therapy. 7) Hypertension: classification, pathogenesis Principles of therapy. 8) Heart failure - Definition Pathogenetic mechanisms Diagnosis Principles of therapy. 9) The stem cells in the treatment of cardiovascular diseases Definition of stem cells.
Identification and use of cardiac stem cells. 10) Cardiomyopathy: definition Pathogenetic mechanisms Major genetic factors.
Diagnosis Principles of therapy The anthracycline- and monoclonal antibodies-induced cardiotoxicity: pathogenic mechanisms.
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|
|
Discipline
|
Module
|
Denomination
|
Medical genetics
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Molecular pathology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
One-module course
|
Denomination
|
Synthesis of biomolecules
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Synthesis of biomolecules
|
Credit
|
5
|
SDS
|
CHIM/06
|
Description
|
Learning objectives: To provide knowledge on the rational design and synthesis of biomolecules having an important biological role such as polypeptides, oligonucleotides and their analogues. Contents: 1) Organic molecules of interest Molecular recognition Drugs and enzyme receptors Natural and synthetic biomolecules. 2) Rational drug design Molecular structure investigation by spectroscopic methods - Nuclear Magnetic Resonance (NMR). - Circular Dichroism spectroscopy - UV-VIS spectroscopy and fluorescence molecules. - X ray diffraction, molecular structure and conformation and literature data. - Mass spectrometry (MALDI and ESI) - Computational methods to obtain molecular structures; 3) Synthesis of biomolecules: Organic-chemical and enzymatic synthesis. - Solid-phase synthesis. - Combinatorial synthesis.. 4) Oligonucleotides synthesis Role and uses of Oligonucleotides as model, diagnostics and drugs Oligonucleotide analogues and conjugated at other molecules Purification 5) Peptides Role and uses of peptides Synthesis of peptides and analogues Peptidomimetics Purifications 6) Reaction and uses of Biomolecules on chip
|
|
|
Discipline
|
Integrated course
|
Denomination
|
Molecular basis of immunological and neurological diseases
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Advanced therapeutic technologies
|
Credit
|
5
|
SDS
|
MED/46
|
Description
|
|
|
Module
|
Development of molecular agents
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
|
|
|
Discipline
|
Module
|
Denomination
|
Advanced therapeutic technologies
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Development of molecular agents
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Molecular basis of immunological and neurological diseases
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Neurology
|
Credit
|
5
|
SDS
|
MED/26
|
Description
|
Learning objectives: To know the tools provided by biotechnology to study the molecular basis of neurological diseases applied to diagnosis and treatment. Contents: 1) Hints of anatomy and physiology of CNS and PNS; CSF and cerebrospinal fluid circulation. 2) Neuron; cytoskeleton; axonal transport; glial cells; myelin; action and resting membrane potential; impulse conduction; synaptic transmission; neurotransmitters; receptors; blood-brain barrier; cerebral metabolism. 3) General information on main neurological syndromes: central and peripheral paralysis; hypokinetic and hyperkinetic extrapyramidal syndromes; cerebellar syndrome; dementia syndromes. 4) Pathogenesis of the main movement disorders: Parkinson's disease, Huntington's disease, Friedreich's ataxia; ataxia from DNA damage repair defect; dominant spinocerebellar ataxias. 5) Pathogenesis of Alzheimer's dementia and frontotemporal dementia; role of amyloid and tau proteins. 6) Impaired copper metabolism diseases: Wilson's disease and Menkes disease. 7) Multiple sclerosis: symptoms and signs, diagnosis and therapy; genetic and environmental pathogenic factors; experimental allergic encephalitis; myelin and axonal damage; humoral and cellular immunity. 8) Dysimmune neuropathies: Guillain-Barré syndrome. 9) Myasthenia gravis. 10) Epilepsy: classification and main clinical basics of seizures; hints of diagnosis and therapy; pathogenesis of seizures; experimental models and human mutations; thalamic-cortical circuits and absence seizures (petit mal). 11) Vascular disease: cerebral circulation; epidemiology and clinical signs of ischemia and cerebral hemorrhage; pathogenesis of cerebral ischemia; genetic causes of cerebral ischemia.
|
|
Module
|
Clinical immunology
|
Credit
|
5
|
SDS
|
MED/09
|
Description
|
Learning objectives: Learning cellular and molecular mechanisms involved in physiological and pathological immune processes Possible applications of biotechnology. Contents: 1) Macrophages 2) Basophils 3) Mast Cells 4) Chemokines 5) T and B lymphocytes 6) Superantigens 7) Immune Deficiency 8) IgA Deficiency 9) Hypogammaglobulinemia 10) Mastocytosis 11) Eosinophils 12) Food Allergy 13) Bronchial Asthma 14) Urticaria 15) Angioedema 16) Drug Allergy 17) Anaphylaxis 18) Systemic Lupus Erythematosus 19) Reumatoid Arthritis 20) Biologic therapy of Rheumatoid Arthritis 21) Anti-IgE Therapy in Allergic Diseases
|
|
|
Discipline
|
Module
|
Denomination
|
Neurology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Clinical immunology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Metodologie e Biotecnologie Avanzate applicate agli alimenti di origine animale
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Metodologie e Biotecnologie Avanzate applicate all’alimentazioni animali
|
Credit
|
5
|
SDS
|
AGR/18
|
Description
|
|
|
Module
|
Metodologie e Biotecnologie Avanzate applicate all’igiene degli alimenti di origine animale
|
Credit
|
5
|
SDS
|
VET/04
|
Description
|
|
|
|
Discipline
|
Module
|
Denomination
|
Metodologie e Biotecnologie Avanzate applicate all’alimentazioni animali
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Metodologie e Biotecnologie Avanzate applicate all’igiene degli alimenti di origine animale
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Food Biotechnology
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Nutrigenomics
|
Credit
|
5
|
SDS
|
AGR/18
|
Description
|
|
|
Module
|
Advanced Biotechnology applied to food hygiene
|
Credit
|
5
|
SDS
|
VET/04
|
Description
|
|
|
|
Discipline
|
Module
|
Denomination
|
Nutrigenomics
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Advanced Biotechnology applied to food hygiene
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Metodologie e Biotecnologie nella diagnostica sperimentale e nell’allevamento animale
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Metodologie e Biotecnologie applicate all’allevamento animale
|
Credit
|
5
|
SDS
|
AGR/19
|
Description
|
|
|
Module
|
Diagnostica sperimentale applicata alle malattie infettive
|
Credit
|
5
|
SDS
|
VET/05
|
Description
|
|
|
|
Discipline
|
Module
|
Denomination
|
Metodologie e Biotecnologie applicate all’allevamento animale
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Diagnostica sperimentale applicata alle malattie infettive
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Biotechnology in experimental diagnostic and animal reproduction
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Advanced Biotechnology in medically assisted procreation
|
Credit
|
5
|
SDS
|
AGR/19
|
Description
|
|
|
Module
|
Experimental diagnostic applied to infectious diseases
|
Credit
|
5
|
SDS
|
VET/05
|
Description
|
|
|
|
Discipline
|
Module
|
Denomination
|
Advanced Biotechnology in medically assisted procreation
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Experimental diagnostic applied to infectious diseases
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
One-module course
|
Denomination
|
Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Bioethics
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Bioethics
|
Credit
|
5
|
SDS
|
MFIL/03
|
Description
|
Learning objectives: The course aims to analyze the issues of bioethics research, highlighting the main aspects of the current debate which involves different cultures and traditions and, in an interdisciplinary perspective, combines different contributions of diverse knowledges, such as science, philosophy, ethics, law Birth, death, health, preservation of the biosphere, possible forms of recognition of non human otherness represent some of the most significant issues to be analyzed during the lessons In particular, the implications and the impact on the public debate of advanced biotechnologies, considered as factors of transformation of biological and historical life, will be discussed in the frame of the course Critical survey will be given to the complexity of the links that exist among scientific research, ethical inquiry, legal regulation, political decision Fundamental objectives of the course are: - Developing knowledges concerning the history, terminology and methodologies of bioethics research; - Promoting skills and independent judgment through contextualization and interpretation of the problems posed by bioethics and biolaw Contents: - Bioethics: the word and the things - The different approaches to bioethics research - Ethics, law and technosciences: the principles of autonomy, responsibility and precaution - Biomedicine and the right to health: human dignity and self-determination - Boundary stones: assisted procreation and assisted death - The frontiers of genetics: the debate on genetic tests and on stem cells - Prerogatives of the human being and of the machine: the post-human - Biotechnology and environment: ecological crisis, biodiversity, GMO - "Food for thought": the food industry between market and informed choice - Ethics and rights of nonhuman beings - National and international documents regarding biotechnologies - Society and biotechnology products and processes: governance of scientific research
|
|
|
Discipline
|
Integrated course
|
Denomination
|
Enabling technologies in cell biology and regenerative medicine
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Advanced cell biology
|
Credit
|
5
|
SDS
|
BIO/13
|
Description
|
|
|
Module
|
Molecular tools in regenerative medicine
|
Credit
|
5
|
SDS
|
BIO/11
|
Description
|
|
|
|
Discipline
|
Module
|
Denomination
|
Advanced cell biology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Molecular tools in regenerative medicine
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Molecular basis of oncological diseases
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Clinical oncology
|
Credit
|
5
|
SDS
|
MED/06
|
Description
|
|
|
Module
|
Experimental oncology
|
Credit
|
5
|
SDS
|
MED/04
|
Description
|
Learning objectives: To learn key mechanisms of neoplastic transformation and new biotechnology principles of precision diagnostics and targeted therapy of cancer Contents: 1) Human neoplasia: classification, etiology, conventional and innovative diagnostic strategies. 2) Phenotypic hallmarks of cancer cells. 3) Molecular basis of cancer Cancer genome Genes and genetic lesions driving cancer formation. 4) Viral and cellular oncogenes Classification, molecular mechanisms of gain-of-function, molecular mechanisms of transforming activity. 5) Tumor suppressor genes Classification: care-takers and gate-keepers, molecular mechanisms of loss-of-function, mechanisms of tumor suppressing activity. 6) Mendelian cancer syndromes. 7) Molecular basis of invasion, angiogenesis and metastases. 8) Molecular features of selected malignancies (breast, prostate, colo-rectal, lung, head/neck and thyroid cancers; melanoma). 9) Molecular diagnosis of cancer. 10) Targeted therapy of cancer New anti-cancer drugs and clinical trials.
|
|
|
Discipline
|
Module
|
Denomination
|
Clinical oncology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Experimental oncology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Integrated course
|
Denomination
|
Molecular basis of oncological and hematological diseases
|
Modules
|
2
|
CFU
|
10
|
This teaching course includes the following modules
Module
|
Hematology
|
Credit
|
5
|
SDS
|
MED/15
|
Description
|
Learning objedctives: To provide comprehensive guidance on : (a) pathophysiologic mechanisms of molecular and cellular basis of most common hematologic malignancies (b) basis of clinical characteristics of most common hematologic malignancies (c) diagnostic procedures (basic, cytologic, molecular) for diagnosis and monitoring of most common hematologic malignancies Contents: 1) Pathophysiology of hematopoietic system 2) Diagnostic process of most common hematologic diseases 3) Pathophysiology of inherited and acquired red blood cell disorders : iron deciciency anemia, megaloblastic anemias, thalassemia syndromes, inherited and autoimmune hemolytic anemia 4) Molecular basis of neoplastic transformation of hematopoietic cells : chromosomal translocations and oncogenes activating mutations, alterations of epigenetic mechanisms, and splicing alterations 5) Overview of leukemic stem cells 6) Pathogenesis, classification, diagnosis and clinical basis of acute and chronic leukemias 7) Pathogenesis, classification, diagnosis and clinical basis of myelodysplastic syndromes : basis of demethylating agents and epigenetic therapy 8) Pathogenesis, classification, diagnosis and clinical basis of most common lymphoproliferative disorders 8) Basic and advanced diagnostic tests in hematology : complete blood count, flow cytometry, immunohistochemistry, cytogenetics and molecular biology. 9) Hematopoietic stem cells transplantation : basic principles, indications and basis of stem cell manipulation
|
|
Module
|
Oncology
|
Credit
|
5
|
SDS
|
MED/04
|
Description
|
Learning objectives: To learn key mechanisms of neoplastic transformation and new biotechnology principles of precision diagnostics and targeted therapy of cancer Contents: 1) Human neoplasia: classification, etiology, conventional and innovative diagnostic strategies. 2) Phenotypic hallmarks of cancer cells. 3) Molecular basis of cancer Cancer genome Genes and genetic lesions driving cancer formation. 4) Viral and cellular oncogenes Classification, molecular mechanisms of gain-of-function, molecular mechanisms of transforming activity. 5) Tumor suppressor genes Classification: care-takers and gate-keepers, molecular mechanisms of loss-of-function, mechanisms of tumor suppressing activity. 6) Mendelian cancer syndromes. 7) Molecular basis of invasion, angiogenesis and metastases. 8) Molecular features of selected malignancies (breast, prostate, colo-rectal, lung, head/neck and thyroid cancers; melanoma). 9) Molecular diagnosis of cancer. 10) Targeted therapy of cancer New anti-cancer drugs and clinical trials.
|
|
|
Discipline
|
Module
|
Denomination
|
Hematology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
Module
|
Denomination
|
Oncology
|
Modules
|
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
|
Denomination
|
Final exam (thesis preparation and defense)
|
Modules
|
|
CFU
|
12
|
This teaching course includes the following modules
|
Discipline
|
|
Denomination
|
Final exam (thesis preparation and defense)
|
Modules
|
|
CFU
|
15
|
This teaching course includes the following modules
|
Discipline
|
|
Denomination
|
Course at student’s choice
|
Modules
|
|
CFU
|
10
|
This teaching course includes the following modules
|
Discipline
|
|
Denomination
|
Internship
|
Modules
|
|
CFU
|
10
|
This teaching course includes the following modules
|
Discipline
|
One-module course
|
Denomination
|
Biotechnology applied to aquafarming
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biotechnology applied to aquafarming
|
Credit
|
5
|
SDS
|
AGR/20
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Advanced diagnostics of additives and residues
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Advanced diagnostics of additives and residues
|
Credit
|
5
|
SDS
|
BIO/12
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biotecnologie applicate alla alimentazione animale
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biotecnologie applicate alla alimentazione animale
|
Credit
|
5
|
SDS
|
AGR/18
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Allevamenti alternativi in aviconiglicoltura
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Allevamenti alternativi in aviconiglicoltura
|
Credit
|
5
|
SDS
|
AGR/20
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Clinical molecular biology in physical activity
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Clinical molecular biology in physical activity
|
Credit
|
5
|
SDS
|
M-EDF/01
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biotechnology applied to poultry and rabbit farming
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biotechnology applied to poultry and rabbit farming
|
Credit
|
5
|
SDS
|
AGR/20
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Developing biomolecules for clinical applications
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Developing biomolecules for clinical applications
|
Credit
|
5
|
SDS
|
BIO/11
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Pharmaceutical Biotechnology
|
Modules
|
1
|
CFU
|
0
|
This teaching course includes the following modules
Module
|
Pharmaceutical Biotechnology
|
Credit
|
0
|
SDS
|
CHIM/08
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Pharmacological Biotechnology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Pharmacological Biotechnology
|
Credit
|
5
|
SDS
|
BIO/14
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Recombinant Biotechnology II
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Recombinant Biotechnology II
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biotecnologie genetiche in zootecnica
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
|
Discipline
|
One-module course
|
Denomination
|
Biochemical methods applied to cell therapy
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biochemical methods applied to cell therapy
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Morphomolecular diagnostic applications in citopathology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Morphomolecular diagnostic applications in citopathology
|
Credit
|
5
|
SDS
|
MED/08
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
MED/09
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
BIO/13
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Endocrinology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Endocrinology
|
Credit
|
5
|
SDS
|
MED/13
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Epidemiology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Epidemiology
|
Credit
|
5
|
SDS
|
MED/42
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Pharmacology and veterinary toxicology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Pharmacology and veterinary toxicology
|
Credit
|
5
|
SDS
|
VET/07
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Functional Genomics
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Functional Genomics
|
Credit
|
5
|
SDS
|
BIO/10
|
Description
|
Contents: 1) Acquisition of experimental and cultural methods underlying the decoding of the human genome. 2) Main software for remote viewing and analysis of the human genome. 3) Impact of genomics in the study of biological problems. 4) Analysis of gene expression through genomic approaches with particular emphasis on RNA-Seq 5) Experimental and methodological principles of genomic analysis of datasets in order to develop a mechanistic understanding of transcriptional control (Chip-seq), with particular emphasis on epigenetic aspects. 6) Experimental and methodological principles for datasets of genomic analysis to the understanding of DNA replication processes (Repli-seq) and DNA repair to genotoxic damage.
|
|
|
Discipline
|
One-module course
|
Denomination
|
Diagnostic imaging
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Diagnostic imaging
|
Credit
|
5
|
SDS
|
MED/36
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Immunobiotechnology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Immunobiotechnology
|
Credit
|
5
|
SDS
|
M-EDF/01
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Anatomy, physiology and integrated imaging of vertebrates
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Anatomy, physiology and integrated imaging of vertebrates
|
Credit
|
5
|
SDS
|
VET/09
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Medicine of ageing and Biotechnology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Medicine of ageing and Biotechnology
|
Credit
|
5
|
SDS
|
MED/09
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Morphomolecular diagnostic applications in histopathology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Morphomolecular diagnostic applications in histopathology
|
Credit
|
5
|
SDS
|
MED/08
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Maricoltura
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Maricoltura
|
Credit
|
5
|
SDS
|
AGR/18
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Internal medicine
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Internal medicine
|
Credit
|
5
|
SDS
|
MED/09
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
MED/07
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biotechnology and improvement of animal genetics
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biotechnology and improvement of animal genetics
|
Credit
|
5
|
SDS
|
AGR/17
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Neurology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Neurology
|
Credit
|
5
|
SDS
|
MED/26
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
OGM and animal dietetics
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
OGM and animal dietetics
|
Credit
|
5
|
SDS
|
AGR/18
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Molecular targets in oncological therapy
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Molecular targets in oncological therapy
|
Credit
|
5
|
SDS
|
MED/06
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Molecular oncology
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Molecular oncology
|
Credit
|
5
|
SDS
|
MED/04
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
MED/04
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biology of human reproduction – Laboratory for medically-assisted procreation
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biology of human reproduction – Laboratory for medically-assisted procreation
|
Credit
|
5
|
SDS
|
MED/40
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biotechnology in transplantations and vascular surgery
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biotechnology in transplantations and vascular surgery
|
Credit
|
5
|
SDS
|
MED/18
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Precision Genomics
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Precision Genomics
|
Credit
|
5
|
SDS
|
MED/03
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Biotecnology in forensic diagnostic
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Biotecnology in forensic diagnostic
|
Credit
|
5
|
SDS
|
BIO/12
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
Clinical molecular biology in physical activity
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
Clinical molecular biology in physical activity
|
Credit
|
5
|
SDS
|
M-EDF/01
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
IUS/14
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
BIO/18
|
Description
|
|
|
|
Discipline
|
One-module course
|
Denomination
|
|
Modules
|
1
|
CFU
|
5
|
This teaching course includes the following modules
Module
|
|
Credit
|
5
|
SDS
|
MED/04
|
Description
|
|
|
|