Course details

Discipline Integrated course
Denomination Biochemistry of complex systems and Bioinformatics
Modules 2
CFU 10



This teaching course includes the following modules
Module Biochemistry
Credit 5
SDS BIO/10
Description Goals:
To provide knowledge on biochemical and molecular mechanisms regulating the metabolic relationship between different organs and / or tissues.
Contents:
1) Metabolism of calcium and phosphate
Role of Vitamin D, parathyroid hormone and calcitonin in calcium and phosphate homeostasis.
2) Biochemistry of bones and teeth
Role of osteoblasts and osteoclasts cells in bone mineralization and bone resorption
Biochemical markers of bone metabolism.
3) Biochemistry of liver
Detoxification and ethanol metabolism.
4) Biochemistry of kidneys
Urine formation
Filtration and reabsorption
Renal metabolism
Endocrine functions of the kidney.
5) Biochemistry of adipose tissue
White and brown adipose tissue
Thermogenesis.
6) Muscle biochemistry
Structural organization
Skeletal muscle cell contraction.
7) Biochemistry of cardiac muscle
Substrate utilization in the myocardium
Mechanism and Contraction Events of Cardiac Muscle Fibers.
8) Biochemistry of cancer-cell metabolism
Warburg effect
Role of Hypoxia-inducible factor 1 in cancer.
9) Biochemistry of the nervous system
Brain metabolism
Neurotransmitters synthesis.
10) Biochemistry of the sensory systems: vision, olfaction, taste, hearing and touch
Module Bioinformatics
Credit 5
SDS BIO/10
Description Learning Objectives:
Provide the students with tools for computational analysis of proteins and genomes.
Contents:
1) Sequence alignment methods
2) Methods for studying protein families
3) Protein structure analysis by similarity search
4) Orphan proteins analysis
5) Search for coding regions in sequenced genomes
6) Search for other functional sequences
7) EST and gene expression analysis
8) Databases
Discipline Module
Denomination Biochemistry
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Bioinformatics
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Microbiology and Microbial Biotechnology
Modules 2
CFU 8



This teaching course includes the following modules
Module Microbial biotechnology
Credit 5
SDS MED/07
Description
Module Molecular and cellular Microbiology
Credit 3
SDS MED/07
Description Learning objectives: Study of the molecular and cellular mechanisms of host-parasite interactions involved in the pathogenesis of infectious diseases
Study of the role of microorganisms in different biotechnological processes and analysis of the potential of genetically modified organisms or wild type as incubators for the production of goods and services applicable in the biomedical field
Contents:
1) Cellular and molecular mechanisms of bacterial pathogenicity: entrance, adhesion, colonization, tissue invasion and permanence; evasion to the immune response; secretion systems; RTX Toxins and production of the damage.
2) Molecular processes of acute and chronic inflammatory response involved in the pathogenesis of infectious diseases
The example of Mycobacterium tuberculosis.
3) Interactions between microbial communities: The bacterial biofilm, Molecular mechanisms of the biofilm formation in Gram-positive and negative bacteria.
4) Quorum sensing: Species-specific and multispecies bacterial interactions
Cellular and molecular mechanisms involved in bacterial interactions and their involvement in the host response.
5) Microorganisms as a tool and as a product in biotechnology; the model systems in biotechnology microbial: Bacteria, Yeast and Viruses.
6) Tools of microbial biotechnology: Plasmids and viruses as cloning vectors
Hosts for cloning
Cloning and expression of heterologous genes.
7) Manipulation of Gene Expression in Prokaryotes: Gene expression from strong and regulatable promoters, Fusion proteins, Unidirectional tandem gene arrays, Translation expression vectors, Increasing protein stability, Protein folding, Overcoming oxygen limitation, DNA integration into the host chromosome, Increasing secretion, Metabolic load.
8) Production of microbial recombinant proteins: Escherichia coli and other bacteria such expression systems, approaches and strategies in the production of proteins of medical biotechnology.
9) Expression in eukaryotic systems: Saccharomyces cerevisiae, Pichia pastoris, others yeast systems, Baculovirus-Insect cells
Description of vectors and promoters (constitutive and inducible) most commonly used; advantages and limitations of the expression systems.
10) Microbial production of protein therapeutics: pharmaceuticals, enzymes, recombinant antibodies, therapeutic agents against HIV.
11) Vaccines: Subunit vaccines (Herpes Simplex Virus, Cholera); Peptide vaccines (Malaria); Genetic immunization (DNA and RNA vaccines); Attenuated vaccines (Cholera, Salmonella species); Vector vaccines (vaccines directed against Bacteria and Viruses, bacteria as antigen delivery systems)
New generation vaccines .
Discipline Module
Denomination Microbial biotechnology
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Molecular and cellular Microbiology
Modules
CFU 3



This teaching course includes the following modules
Discipline One-module course
Denomination Molecular and cellular Microbiology
Modules 1
CFU 5



This teaching course includes the following modules
Module Molecular and cellular Microbiology
Credit 5
SDS MED/07
Description
Discipline Integrated course
Denomination Developmental Biology and control of gene expression
Modules 2
CFU 10



This teaching course includes the following modules
Module Biology
Credit 5
SDS BIO/13
Description Learning objectives: 
Students are expected to acquire knowledge and competence regarding the main molecular mechanisms that underlie development of multicellular organisms
Major focus will be on the main animal models used as tools in basic and biotecnological research
Contents:
1) Basic principles and modules in cell communication: Notch, Wnt, Hedgehog and TGFb based signaling pathways
Endocytosis in signaling pathways regulation
Signaling integration during development of multicellular organisms.
2) Universal mechanisms of animal development: basic animal body plan, transcriptional control, regulatory DNA, combinatorial control, cell memory, morphogens, inductive signal gradients, asymmetric cell division, sequential induction 
3) Mechanisms of pattern formation in Drosophila melanogaster and amphibians.
4) Developmental timing, morphogenesis and growth.
5) Regeneration of the epithelial surface in the small intestine; fibroblasts and their transformations; the connective tissue family; the growth and remodelling of cartilage and bone; the growth and regeneration of blood vessels and endothelial cells; the bone marrow and the blood cells; scheme of haematopoiesis; genesis and regeneration of skeletal muscle.
6) Mouse: differentiation events before implantation, ES cells, transgenic mice generation
Module Molecular Biology
Credit 5
SDS BIO/11
Description Learning objectives:
The aim is to provide knowledge about the technologies of gene expression and transfer in vitro and in vivo and of gene editing for medical applications in the fields of vaccination, passive immunotherapy and genetic dysfunction
Understanding of some fundamental mechanisms regulating gene expression and in turn cell identity and fate.
Contents:
1) Homologous recombination and recombineering
Engineering of expression vectors by homologous recombination
The mechanisms of homologous recombination in prokaryotes will be described with particular attention to those usable for biotechnological applications.
2) Genome editing in a dish and in vivo
Use of zinc finger nucleases, Talen and CAS9/CRISP
Description of the new technologies of genome editing using site-specific nucleases and their use to generate mutants and cell lines expressing therapeutic protein.
3) Genome editing applications focused to human therapy
Applications of genome editing using site-specific nucleases for the therapy of genetic diseases.
4) Gene expression regulation in the determination of cell fate
a) Transcription factors
The function of master genes in the early phases of development
B) microRNAs
The fine regulation of gene expression at post-transcriptional level
C) ceRNAs
The recent discovery of post-transcriptional gene regulation.
Discipline Module
Denomination Biology
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Molecular Biology
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Advanced diagnostics
Modules 2
CFU 10



This teaching course includes the following modules
Module Molecular diagnostics
Credit 5
SDS BIO/12
Description Learning objectives:
Knowledge of basic and advanced methodologies for the molecular analysis and for the identification of disease-associated genes
Rationale of direct type genetic testing to detect disease-associated genetic variants; of indirect type genetic testing, to look at the segregation of a disease with genetic markers; of linkage analysis for identifying genome regions that are implicated in disease traits
Interpretation of molecular results.
Contents:
1
Introduction to molecular diagnostics.
- Transmission mode and heterogeneity in genetic diseases.
- Variable penetrance and expressivity
Genotype-phenotype correlation.
- Post-natal and prenatal diagnosis; genetic counseling.
- Types of mutation
Pathogenic mechanisms and validation of mutations.
2
Advanced methods for identifying genetic variants
- Surveyor Nuclease, microarrays or DNA chips.
- High-throughput DNA sequencing.
- TP-PCR, MLPA, qPCR, CGH array.
- Microsatellite instability.
3
Applied molecular diagnostics
- Molecular diagnosis of monogenic inherited diseases.
- Molecular diagnosis of genetically heterogeneous disorders.
- Molecular diagnosis of triplet repeat disorders.
- Molecular diagnosis of inherited cancers and hemolymphoproliferative diseases.
- Molecular diagnosis of genomic imprinting-associated diseases.
4
Discussion of selected case studies and formal mode of reporting.
Module Laboratory Medicine methods
Credit 5
SDS MED/46
Description Learning objectives:
Students are expected to develop the critical capacity for using the most advanced laboratory methods (in addition to traditional biochemical markers) in order to assess human organs and tissues functionality.
Contents:
1) The specialized laboratory of Clinical Biochemistry
- Decision analysis.
- Evidence Based Approach.
- Clinic interface.
2) Examples of clinical biochemistry and molecular biology diagnosis integration in the clinical evaluation of organs and systems.
- Integrated laboratory evaluation of liver function
- Integrated laboratory evaluation of exocrine pancreas function
Hereditary pancreatitis.
- Integrated laboratory evaluation of cardiac activity abnormalities; the laboratory role in the diagnosis and prevention of cardiovascular diseases.
- Integrated laboratory evaluation of kidney function
- Hemostasis and coagulation: integrated diagnostics of hemophilia
- Integrated laboratory evaluation of recessive diseases: Cystic Fibrosis
Discipline Module
Denomination Molecular diagnostics
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Laboratory Medicine methods
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination System Pharmacology and Cellular and Gene Therapy
Modules 2
CFU 10



This teaching course includes the following modules
Module System Pharmacology and pharmacogenetics
Credit 5
SDS BIO/14
Description Learning objectives:
At the end of the course, students are expected to acquire knowledge and competence regarding the main classes of drugs for the treatment of human diseases
In particular, major focus will be on the molecular targets of drug action, and on the genetic basis of the interindividual and interethnic variability in drug response.
Contents:
1
Historical background, significance and clinical relevance of pharmacogenetis and pharmacogenomics for drug efficacy and toxicity prediction
2
Pharmacology and pharmacogenetics of drugs acting on the gastrointestinal system: agents for the control of gastric acidity and peptic ulcers, laxatives, antidiarrheal drugs, antiemetics and drugs against motion sickness
3
Pharmacology and pharmacogenetics of drugs acting on the endocrine system: oestrogens, progestins, hormonal contraceptives, corticosteroids.
4
Pharmacology and pharmacogenetics of drugs acting on the central nervous system: antipsychotics, antidepressants, hypnotics and sedatives, anticonvulsants, opioid analgesics, drugs for the treatment of neurodegenerative diseases (anti-Parkinson, anti-Alzheimer)
Pharmacogenomics of the blood-brain barrier and drug resistance.
5
Pharmacology and pharmacogenetics of drug addiction (cocaine, MDMA, other psychostimulants).
6
Pharmacology and pharmacogenetics of drugs acting on the cardiovascular system: blood pressure lowering agents, diuretics, drugs against heart failure
Genetic basis of drug-induced arrhythmias
7
Pharmacology and pharmacogenetics of lipid-lowering drugs.
8
Pharmacology and pharmacogenetics of antiasthmatics
9
Pharmacology and pharmacogenetics of antidiabetic drugs: insulin, oral hypoglycemics
10
Pharmacology and pharmacogenetics of anti-platelet drugs and anticoagulants.
11
Pharmacology and pharmacogenetics of antineoplastics.
Module Cellular and Gene Therapy
Credit 5
SDS BIO/12
Description Learning objectives:
The aim of the course is to provide students with knowledge and elements of critical discussion on the methodological approaches for gene and cell therapy as well as applications of these methods in both animal models and humans.
Contents:
1) Overview of gene therapy - Definition of vectors and target cells; types of transgenes and applications; regulation of the expression; primary cell cultures; cell banking, and applications of flow cytometry and cell sorting; regulatory aspects of the production of drugs for gene and cell therapy.
2) non-viral vectors – naked plasmids; physical and chemical methods for DNA transfer and their applications; RNA interference and its main applications for therapeutic purposes.
3) adenoviral vectors - Types of adenoviral vectors; toxicity; applications in vaccine and gene therapy.
4) AAV Vectors – vector development; identification of serotypes for alternative tropism; main applications in therapy.
5) Retroviral and lentiviral vectors - Features carriers and differences; pseudotyping; methods of production also for clinical use.
6) stem cells - Definition; Embryonic stem cells; generation, use and applications in gene therapy; Stem cells from adult tissues; Stem cells from bone marrow and use in regenerative medicine; iPS cells and their applications.
7) Tissue regeneration - Identification and use of cells with osteoblastic potential and strategies to induce osteoblastic differentiation; regeneration of epidermis and cornea; identification and culture of stem cells for specific applications; biomaterials and their use in regenerative medicine.
8) Gene therapy of inherited diseases - Development and applications of gene therapy strategy for the treatment of metabolic diseases in humans; Gene therapy for congenital immunodeficiencies and applications in humans; genotoxicity and potential solutions.
9) Gene and regenerative therapy for common diseases - therapy of cardiovascular diseases and regeneration of cardiac tissue; development of medical devices for gene transfer; regeneration of myocardial tissue by reprogramming; therapeutic angiogenesis; gene and cell therapy of diabetes mellitus.
10) Gene therapy from bench to bedside: study of the development of gene therapy drugs from the evaluation of the metabolic disease to the marketing of the drug for gene therapy.
Discipline Module
Denomination System Pharmacology and pharmacogenetics
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Cellular and Gene Therapy
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Genetics and molecular pathology
Modules 2
CFU 10



This teaching course includes the following modules
Module Medical genetics
Credit 5
SDS MED/03
Description Learning Objectives:
Students are expected to understand the genetic bases of mendelian and complex diseases, analyzed by classic genetic approaches and by functional genomics.
Contents:
MONOGENIC AND MULTIFACTORIAL INHERITANCE - Mendelian inherited diseases
Molecular bases of haemoglobinopathies
Genetic counseling
Complex traits and multifactorial inheritance
Modifier genes and susceptibility genes.
HUMAN GENOME ORGANIZATION AND VARIATION - Normal and pathogenic DNA variants
The non-coding genome: structure and function of novel classes of small and long non-coding RNAs
HUMAN GENE EXPRESSION - Chromatin conformation: DNA methylation and the histone code
A comprehensive overview of transcription and its control: the ENCODE project
Mosaicism and chimerism in humans
Epigenetic memory and imprinting
Molecular bases of X-inactivation and imprinting.
GENOMEWIDE VIEW OF COMMON HUMAN DISEASES - Advanced approaches to the Identification of disease genes
The genomics of cancer
Tumor markers
Therapeutic targets in cancer
STUDYING HUMAN CHROMOSOMES - Classic cytogenetic analysis
Molecular cytogenetics: FISH, chromosome painting, multicolor FISH, SKY, bandeggio multicolore, chromosome painting parziale regione-specifica, array CGH e CNV
PRINCIPLES OF DEVELOPMENT - Early human development
Cell specialization, pattern formation and morphogenesis
Definition and classification of birth defects.
EVOLUTIONARY GENETICS - Evolution of genes and traits
Natural selection
Molecular evolution and the neutral theory
Evolutionary forces shaping human genome organization and function.
POPULATION GENETICS - Factors affecting allele frequencies in human populations
Using the Hardy-Weinberg relationship in genetic counseling
DNA profiling and forensic genetics.
Module Molecular pathology
Credit 5
SDS MED/04
Description Learning objectives:
Knowledge of the basic processes underlying cardiovascular disease: myocardial ischemia, hypertension, cardiomyopathy, heart failure, lipid metabolism, atherosclerosis, Obesity, Metabolic syndrome.
Learning of the most advanced methods for the diagnosis and molecular therapy of these diseases
Mechanisms of cell death: apoptosis, autophagy, entosis, necroptosis.
Contents:
1) Mechanisms of cell death
Necrosis, apoptosis, autophagy, entosis.
2) Lipid metabolism
Lipoproteins, endogenous and exogenous metabolism.
3) Hyperlipidemias: classification, identification of major genetic defects underlying the most common forms
Medical management based on the knowledge of the pathways of lipid biosynthesis.
4) Obesity: mechanisms regulating food introit
Role of the hypothalamus
Leptin, the Neuropeptide Y, the MSH Receptor
Advantages of the study of animal models of obesity.
5) Pathophysiology of atherosclerosis
Features of the blood vessel
Cellular and molecular components involved in the formation of plaque
The pathogenetic hypotheses of atherosclerosis
Methods of invasive cardiology for the treatment of coronary lesions
The coronary angioplasty, stents, drug-eluting stents.
6) The ischemic heart disease
Definition
Pathogenetic mechanisms
Diagnosis
Principles of therapy.
7) Hypertension: classification, pathogenesis
Principles of therapy.
8) Heart failure - Definition
Pathogenetic mechanisms
Diagnosis
Principles of therapy.
9) The stem cells in the treatment of cardiovascular diseases
Definition of stem cells.
Identification and use of cardiac stem cells.
10) Cardiomyopathy: definition
Pathogenetic mechanisms
Major genetic factors.
Diagnosis
Principles of therapy
The anthracycline- and monoclonal antibodies-induced cardiotoxicity: pathogenic mechanisms.
Discipline Module
Denomination Medical genetics
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Molecular pathology
Modules
CFU 5



This teaching course includes the following modules
Discipline One-module course
Denomination Synthesis of biomolecules
Modules 1
CFU 5



This teaching course includes the following modules
Module Synthesis of biomolecules
Credit 5
SDS CHIM/06
Description Learning objectives:
To provide knowledge on the rational design and synthesis of biomolecules having an important biological role such as polypeptides, oligonucleotides and their analogues.
Contents:
1) Organic molecules of interest
Molecular recognition
Drugs and enzyme receptors
Natural and synthetic biomolecules.
2) Rational drug design
Molecular structure investigation by spectroscopic methods
- Nuclear Magnetic Resonance (NMR).
- Circular Dichroism spectroscopy
- UV-VIS spectroscopy and fluorescence molecules.
- X ray diffraction, molecular structure and conformation and literature data.
- Mass spectrometry (MALDI and ESI)
- Computational methods to obtain molecular structures;
3) Synthesis of biomolecules: Organic-chemical and enzymatic synthesis.
- Solid-phase synthesis.
- Combinatorial synthesis..
4) Oligonucleotides synthesis
Role and uses of Oligonucleotides as model, diagnostics and drugs
Oligonucleotide analogues and conjugated at other molecules
Purification
5) Peptides
Role and uses of peptides
Synthesis of peptides and analogues
Peptidomimetics
Purifications
6) Reaction and uses of Biomolecules on chip
Discipline Integrated course
Denomination Molecular basis of immunological and neurological diseases
Modules 2
CFU 10



This teaching course includes the following modules
Module Advanced therapeutic technologies
Credit 5
SDS MED/46
Description
Module Development of molecular agents
Credit 5
SDS BIO/10
Description
Discipline Module
Denomination Advanced therapeutic technologies
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Development of molecular agents
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Molecular basis of immunological and neurological diseases
Modules 2
CFU 10



This teaching course includes the following modules
Module Neurology
Credit 5
SDS MED/26
Description Learning objectives:
To know the tools provided by biotechnology to study the molecular basis of neurological diseases applied to diagnosis and treatment.
Contents:
1) Hints of anatomy and physiology of CNS and PNS; CSF and cerebrospinal fluid circulation.
2) Neuron; cytoskeleton; axonal transport; glial cells; myelin; action and resting membrane potential; impulse conduction; synaptic transmission; neurotransmitters; receptors; blood-brain barrier; cerebral metabolism.
3) General information on main neurological syndromes: central and peripheral paralysis; hypokinetic and hyperkinetic extrapyramidal syndromes; cerebellar syndrome; dementia syndromes.
4) Pathogenesis of the main movement disorders: Parkinson's disease, Huntington's disease, Friedreich's ataxia; ataxia from DNA damage repair defect; dominant spinocerebellar ataxias.
5) Pathogenesis of Alzheimer's dementia and frontotemporal dementia; role of amyloid and tau proteins.
6) Impaired copper metabolism diseases: Wilson's disease and Menkes disease.
7) Multiple sclerosis: symptoms and signs, diagnosis and therapy; genetic and environmental pathogenic factors; experimental allergic encephalitis; myelin and axonal damage; humoral and cellular immunity.
8) Dysimmune neuropathies: Guillain-Barré syndrome.
9) Myasthenia gravis.
10) Epilepsy: classification and main clinical basics of seizures; hints of diagnosis and therapy; pathogenesis of seizures; experimental models and human mutations; thalamic-cortical circuits and absence seizures (petit mal).
11) Vascular disease: cerebral circulation; epidemiology and clinical signs of ischemia and cerebral hemorrhage; pathogenesis of cerebral ischemia; genetic causes of cerebral ischemia.
Module Clinical immunology
Credit 5
SDS MED/09
Description Learning objectives:
Learning cellular and molecular mechanisms involved in physiological and pathological immune processes
Possible applications of biotechnology.
Contents:
1) Macrophages
2) Basophils
3) Mast Cells
4) Chemokines
5) T and B lymphocytes
6) Superantigens
7) Immune Deficiency
8) IgA Deficiency
9) Hypogammaglobulinemia
10) Mastocytosis
11) Eosinophils
12) Food Allergy
13) Bronchial Asthma
14) Urticaria
15) Angioedema
16) Drug Allergy
17) Anaphylaxis
18) Systemic Lupus Erythematosus
19) Reumatoid Arthritis
20) Biologic therapy of Rheumatoid Arthritis
21) Anti-IgE Therapy in Allergic Diseases
Discipline Module
Denomination Neurology
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Clinical immunology
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Metodologie e Biotecnologie Avanzate applicate agli alimenti di origine animale
Modules 2
CFU 10



This teaching course includes the following modules
Module Metodologie e Biotecnologie Avanzate applicate all’alimentazioni animali
Credit 5
SDS AGR/18
Description
Module Metodologie e Biotecnologie Avanzate applicate all’igiene degli alimenti di origine animale
Credit 5
SDS VET/04
Description
Discipline Module
Denomination Metodologie e Biotecnologie Avanzate applicate all’alimentazioni animali
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Metodologie e Biotecnologie Avanzate applicate all’igiene degli alimenti di origine animale
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Food Biotechnology
Modules 2
CFU 10



This teaching course includes the following modules
Module Nutrigenomics
Credit 5
SDS AGR/18
Description
Module Advanced Biotechnology applied to food hygiene
Credit 5
SDS VET/04
Description
Discipline Module
Denomination Nutrigenomics
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Advanced Biotechnology applied to food hygiene
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Metodologie e Biotecnologie nella diagnostica sperimentale e nell’allevamento animale
Modules 2
CFU 10



This teaching course includes the following modules
Module Metodologie e Biotecnologie applicate all’allevamento animale
Credit 5
SDS AGR/19
Description
Module Diagnostica sperimentale applicata alle malattie infettive
Credit 5
SDS VET/05
Description
Discipline Module
Denomination Metodologie e Biotecnologie applicate all’allevamento animale
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Diagnostica sperimentale applicata alle malattie infettive
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Biotechnology in experimental diagnostic and animal reproduction
Modules 2
CFU 10



This teaching course includes the following modules
Module Advanced Biotechnology in medically assisted procreation
Credit 5
SDS AGR/19
Description
Module Experimental diagnostic applied to infectious diseases
Credit 5
SDS VET/05
Description
Discipline Module
Denomination Advanced Biotechnology in medically assisted procreation
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Experimental diagnostic applied to infectious diseases
Modules
CFU 5



This teaching course includes the following modules
Discipline One-module course
Denomination Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
Modules 1
CFU 5



This teaching course includes the following modules
Module Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
Credit 5
SDS BIO/10
Description
Discipline One-module course
Denomination Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
Modules 1
CFU 5



This teaching course includes the following modules
Module Expanding the word of RNA: role of post-trascriptional mechanism in gene regulation
Credit 5
SDS BIO/10
Description
Discipline One-module course
Denomination Bioethics
Modules 1
CFU 5



This teaching course includes the following modules
Module Bioethics
Credit 5
SDS MFIL/03
Description Learning objectives:
The course aims to analyze the issues of bioethics research, highlighting the main aspects of the current debate which involves different cultures and traditions and, in an interdisciplinary perspective, combines different contributions of diverse knowledges, such as science, philosophy, ethics, law
Birth, death, health, preservation of the biosphere, possible forms of recognition of non human otherness represent some of the most significant issues to be analyzed during the lessons
In particular, the implications and the impact on the public debate of advanced biotechnologies, considered as factors of transformation of biological and historical life, will be discussed in the frame of the course
Critical survey will be given to the complexity of the links that exist among scientific research, ethical inquiry, legal regulation, political decision
Fundamental objectives of the course are:
- Developing knowledges concerning the history, terminology and methodologies of bioethics research;
- Promoting skills and independent judgment through contextualization and interpretation of the problems posed by bioethics and biolaw
Contents:
- Bioethics: the word and the things
- The different approaches to bioethics research
- Ethics, law and technosciences: the principles of autonomy, responsibility and precaution
- Biomedicine and the right to health: human dignity and self-determination
- Boundary stones: assisted procreation and assisted death
- The frontiers of genetics: the debate on genetic tests and on stem cells
- Prerogatives of the human being and of the machine: the post-human
- Biotechnology and environment: ecological crisis, biodiversity, GMO
- "Food for thought": the food industry between market and informed choice
- Ethics and rights of nonhuman beings
- National and international documents regarding biotechnologies
- Society and biotechnology products and processes: governance of scientific research
Discipline Integrated course
Denomination Enabling technologies in cell biology and regenerative medicine
Modules 2
CFU 10



This teaching course includes the following modules
Module Advanced cell biology
Credit 5
SDS BIO/13
Description
Module Molecular tools in regenerative medicine
Credit 5
SDS BIO/11
Description
Discipline Module
Denomination Advanced cell biology
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Molecular tools in regenerative medicine
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Molecular basis of oncological diseases
Modules 2
CFU 10



This teaching course includes the following modules
Module Clinical oncology
Credit 5
SDS MED/06
Description
Module Experimental oncology
Credit 5
SDS MED/04
Description Learning objectives:
To learn key mechanisms of neoplastic transformation and new biotechnology principles of precision diagnostics and targeted therapy of cancer
Contents:
1) Human neoplasia: classification, etiology, conventional and innovative diagnostic strategies.
2) Phenotypic hallmarks of cancer cells.
3) Molecular basis of cancer
Cancer genome
Genes and genetic lesions driving cancer formation.
4) Viral and cellular oncogenes
Classification, molecular mechanisms of gain-of-function, molecular mechanisms of transforming activity.
5) Tumor suppressor genes
Classification: care-takers and gate-keepers, molecular mechanisms of loss-of-function, mechanisms of tumor suppressing activity.
6) Mendelian cancer syndromes.
7) Molecular basis of invasion, angiogenesis and metastases.
8) Molecular features of selected malignancies (breast, prostate, colo-rectal, lung, head/neck and thyroid cancers; melanoma).
9) Molecular diagnosis of cancer.
10) Targeted therapy of cancer
New anti-cancer drugs and clinical trials.
Discipline Module
Denomination Clinical oncology
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Experimental oncology
Modules
CFU 5



This teaching course includes the following modules
Discipline Integrated course
Denomination Molecular basis of oncological and hematological diseases
Modules 2
CFU 10



This teaching course includes the following modules
Module Hematology
Credit 5
SDS MED/15
Description Learning objedctives:
To provide comprehensive guidance on :
(a) pathophysiologic mechanisms of molecular and cellular basis of most common hematologic malignancies (b) basis of clinical characteristics of most common hematologic malignancies
(c) diagnostic procedures (basic, cytologic, molecular) for diagnosis and monitoring of most common hematologic malignancies
Contents:
1) Pathophysiology of hematopoietic system
2) Diagnostic process of most common hematologic diseases
3) Pathophysiology of inherited and acquired red blood cell disorders : iron deciciency anemia, megaloblastic anemias, thalassemia syndromes, inherited and autoimmune hemolytic anemia
4) Molecular basis of neoplastic transformation of hematopoietic cells : chromosomal translocations and oncogenes activating mutations, alterations of epigenetic mechanisms, and splicing alterations
5) Overview of leukemic stem cells
6) Pathogenesis, classification, diagnosis and clinical basis of acute and chronic leukemias
7) Pathogenesis, classification, diagnosis and clinical basis of myelodysplastic syndromes : basis of demethylating agents and epigenetic therapy
8) Pathogenesis, classification, diagnosis and clinical basis of most common lymphoproliferative disorders
8) Basic and advanced diagnostic tests in hematology : complete blood count, flow cytometry, immunohistochemistry, cytogenetics and molecular biology.
9) Hematopoietic stem cells transplantation : basic principles, indications and basis of stem cell manipulation
Module Oncology
Credit 5
SDS MED/04
Description Learning objectives:
To learn key mechanisms of neoplastic transformation and new biotechnology principles of precision diagnostics and targeted therapy of cancer
Contents:
1) Human neoplasia: classification, etiology, conventional and innovative diagnostic strategies.
2) Phenotypic hallmarks of cancer cells.
3) Molecular basis of cancer
Cancer genome
Genes and genetic lesions driving cancer formation.
4) Viral and cellular oncogenes
Classification, molecular mechanisms of gain-of-function, molecular mechanisms of transforming activity.
5) Tumor suppressor genes
Classification: care-takers and gate-keepers, molecular mechanisms of loss-of-function, mechanisms of tumor suppressing activity.
6) Mendelian cancer syndromes.
7) Molecular basis of invasion, angiogenesis and metastases.
8) Molecular features of selected malignancies (breast, prostate, colo-rectal, lung, head/neck and thyroid cancers; melanoma).
9) Molecular diagnosis of cancer.
10) Targeted therapy of cancer
New anti-cancer drugs and clinical trials.
Discipline Module
Denomination Hematology
Modules
CFU 5



This teaching course includes the following modules
Discipline Module
Denomination Oncology
Modules
CFU 5



This teaching course includes the following modules
Discipline
Denomination Final exam (thesis preparation and defense)
Modules
CFU 12



This teaching course includes the following modules
Discipline
Denomination Final exam (thesis preparation and defense)
Modules
CFU 15



This teaching course includes the following modules
Discipline
Denomination Course at student’s choice
Modules
CFU 10



This teaching course includes the following modules
Discipline
Denomination Internship
Modules
CFU 10



This teaching course includes the following modules
Discipline One-module course
Denomination Biotechnology applied to aquafarming
Modules 1
CFU 5



This teaching course includes the following modules
Module Biotechnology applied to aquafarming
Credit 5
SDS AGR/20
Description
Discipline One-module course
Denomination Advanced diagnostics of additives and residues
Modules 1
CFU 5



This teaching course includes the following modules
Module Advanced diagnostics of additives and residues
Credit 5
SDS BIO/12
Description
Discipline One-module course
Denomination Biotecnologie applicate alla alimentazione animale
Modules 1
CFU 5



This teaching course includes the following modules
Module Biotecnologie applicate alla alimentazione animale
Credit 5
SDS AGR/18
Description
Discipline One-module course
Denomination Allevamenti alternativi in aviconiglicoltura
Modules 1
CFU 5



This teaching course includes the following modules
Module Allevamenti alternativi in aviconiglicoltura
Credit 5
SDS AGR/20
Description
Discipline One-module course
Denomination Clinical molecular biology in physical activity
Modules 1
CFU 5



This teaching course includes the following modules
Module Clinical molecular biology in physical activity
Credit 5
SDS M-EDF/01
Description
Discipline One-module course
Denomination Biotechnology applied to poultry and rabbit farming
Modules 1
CFU 5



This teaching course includes the following modules
Module Biotechnology applied to poultry and rabbit farming
Credit 5
SDS AGR/20
Description
Discipline One-module course
Denomination Developing biomolecules for clinical applications
Modules 1
CFU 5



This teaching course includes the following modules
Module Developing biomolecules for clinical applications
Credit 5
SDS BIO/11
Description
Discipline One-module course
Denomination Pharmaceutical Biotechnology
Modules 1
CFU 0



This teaching course includes the following modules
Module Pharmaceutical Biotechnology
Credit 0
SDS CHIM/08
Description
Discipline One-module course
Denomination Pharmacological Biotechnology
Modules 1
CFU 5



This teaching course includes the following modules
Module Pharmacological Biotechnology
Credit 5
SDS BIO/14
Description
Discipline One-module course
Denomination Recombinant Biotechnology II
Modules 1
CFU 5



This teaching course includes the following modules
Module Recombinant Biotechnology II
Credit 5
SDS BIO/10
Description
Discipline One-module course
Denomination Biotecnologie genetiche in zootecnica
Modules 1
CFU 5



This teaching course includes the following modules
Discipline One-module course
Denomination Biochemical methods applied to cell therapy
Modules 1
CFU 5



This teaching course includes the following modules
Module Biochemical methods applied to cell therapy
Credit 5
SDS BIO/10
Description
Discipline One-module course
Denomination Morphomolecular diagnostic applications in citopathology
Modules 1
CFU 5



This teaching course includes the following modules
Module Morphomolecular diagnostic applications in citopathology
Credit 5
SDS MED/08
Description
Discipline One-module course
Denomination
Modules 1
CFU 5



This teaching course includes the following modules
Module
Credit 5
SDS MED/09
Description
Discipline One-module course
Denomination
Modules 1
CFU 5



This teaching course includes the following modules
Module
Credit 5
SDS MED/07
Description
Discipline One-module course
Denomination Endocrinology
Modules 1
CFU 5



This teaching course includes the following modules
Module Endocrinology
Credit 5
SDS MED/13
Description
Discipline One-module course
Denomination Epidemiology
Modules 1
CFU 5



This teaching course includes the following modules
Module Epidemiology
Credit 5
SDS MED/42
Description
Discipline One-module course
Denomination Pharmacology and veterinary toxicology
Modules 1
CFU 5



This teaching course includes the following modules
Module Pharmacology and veterinary toxicology
Credit 5
SDS VET/07
Description
Discipline One-module course
Denomination Functional Genomics
Modules 1
CFU 5



This teaching course includes the following modules
Module Functional Genomics
Credit 5
SDS BIO/10
Description Contents:
1) Acquisition of experimental and cultural methods underlying the decoding of the human genome.
2) Main software for remote viewing and analysis of the human genome.
3) Impact of genomics in the study of biological problems.
4) Analysis of gene expression through genomic approaches with particular emphasis on RNA-Seq
5) Experimental and methodological principles of genomic analysis of datasets in order to develop a mechanistic understanding of transcriptional control (Chip-seq), with particular emphasis on epigenetic aspects.
6) Experimental and methodological principles for datasets of genomic analysis to the understanding of DNA replication processes (Repli-seq) and DNA repair to genotoxic damage.
Discipline One-module course
Denomination Diagnostic imaging
Modules 1
CFU 5



This teaching course includes the following modules
Module Diagnostic imaging
Credit 5
SDS MED/36
Description
Discipline One-module course
Denomination Immunobiotechnology
Modules 1
CFU 5



This teaching course includes the following modules
Module Immunobiotechnology
Credit 5
SDS M-EDF/01
Description
Discipline One-module course
Denomination Anatomy, physiology and integrated imaging of vertebrates
Modules 1
CFU 5



This teaching course includes the following modules
Module Anatomy, physiology and integrated imaging of vertebrates
Credit 5
SDS VET/09
Description
Discipline One-module course
Denomination Medicine of ageing and Biotechnology
Modules 1
CFU 5



This teaching course includes the following modules
Module Medicine of ageing and Biotechnology
Credit 5
SDS MED/09
Description
Discipline One-module course
Denomination Morphomolecular diagnostic applications in histopathology
Modules 1
CFU 5



This teaching course includes the following modules
Module Morphomolecular diagnostic applications in histopathology
Credit 5
SDS MED/08
Description
Discipline One-module course
Denomination Maricoltura
Modules 1
CFU 5



This teaching course includes the following modules
Module Maricoltura
Credit 5
SDS AGR/18
Description
Discipline One-module course
Denomination Internal medicine
Modules 1
CFU 5



This teaching course includes the following modules
Module Internal medicine
Credit 5
SDS MED/09
Description
Discipline One-module course
Denomination
Modules 1
CFU 5



This teaching course includes the following modules
Module
Credit 5
SDS MED/07
Description
Discipline One-module course
Denomination Biotechnology and improvement of animal genetics
Modules 1
CFU 5



This teaching course includes the following modules
Module Biotechnology and improvement of animal genetics
Credit 5
SDS AGR/17
Description
Discipline One-module course
Denomination Neurology
Modules 1
CFU 5



This teaching course includes the following modules
Module Neurology
Credit 5
SDS MED/26
Description
Discipline One-module course
Denomination OGM and animal dietetics
Modules 1
CFU 5



This teaching course includes the following modules
Module OGM and animal dietetics
Credit 5
SDS AGR/18
Description
Discipline One-module course
Denomination Molecular targets in oncological therapy
Modules 1
CFU 5



This teaching course includes the following modules
Module Molecular targets in oncological therapy
Credit 5
SDS MED/06
Description
Discipline One-module course
Denomination Molecular oncology
Modules 1
CFU 5



This teaching course includes the following modules
Module Molecular oncology
Credit 5
SDS MED/04
Description
Discipline One-module course
Denomination
Modules 1
CFU 5



This teaching course includes the following modules
Module
Credit 5
SDS MED/04
Description
Discipline One-module course
Denomination Biology of human reproduction – Laboratory for medically-assisted procreation
Modules 1
CFU 5



This teaching course includes the following modules
Module Biology of human reproduction – Laboratory for medically-assisted procreation
Credit 5
SDS MED/40
Description
Discipline One-module course
Denomination Biotechnology in transplantations and vascular surgery
Modules 1
CFU 5



This teaching course includes the following modules
Module Biotechnology in transplantations and vascular surgery
Credit 5
SDS MED/18
Description
Discipline One-module course
Denomination Precision Genomics
Modules 1
CFU 5



This teaching course includes the following modules
Module Precision Genomics
Credit 5
SDS MED/03
Description
Discipline One-module course
Denomination Biotecnology in forensic diagnostic
Modules 1
CFU 5



This teaching course includes the following modules
Module Biotecnology in forensic diagnostic
Credit 5
SDS BIO/12
Description
Discipline One-module course
Denomination Clinical molecular biology in physical activity
Modules 1
CFU 5



This teaching course includes the following modules
Module Clinical molecular biology in physical activity
Credit 5
SDS M-EDF/01
Description
Discipline One-module course
Denomination
Modules 1
CFU 5



This teaching course includes the following modules
Module
Credit 5
SDS IUS/14
Description
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