Biochemistry of complex systems and Bioinformatics
Discipline
Integrated course
Denomination
Biochemistry of complex systems and Bioinformatics
Modules
2
CFU
10
This teaching course includes the following modules
Module
Biochemistry
Credit
5
SDS
BIO/10
Description
Goals: To provide knowledge on biochemical and molecular mechanisms regulating the metabolic relationship between different organs and / or tissues. Contents: 1) Metabolism of calcium and phosphate Role of Vitamin D, parathyroid hormone and calcitonin in calcium and phosphate homeostasis. 2) Biochemistry of bones and teeth Role of osteoblasts and osteoclasts cells in bone mineralization and bone resorption Biochemical markers of bone metabolism. 3) Biochemistry of liver Detoxification and ethanol metabolism. 4) Biochemistry of kidneys Urine formation Filtration and reabsorption Renal metabolism Endocrine functions of the kidney. 5) Biochemistry of adipose tissue White and brown adipose tissue Thermogenesis. 6) Muscle biochemistry Structural organization Skeletal muscle cell contraction. 7) Biochemistry of cardiac muscle Substrate utilization in the myocardium Mechanism and Contraction Events of Cardiac Muscle Fibers. 8) Biochemistry of cancer-cell metabolism Warburg effect Role of Hypoxia-inducible factor 1 in cancer. 9) Biochemistry of the nervous system Brain metabolism Neurotransmitters synthesis. 10) Biochemistry of the sensory systems: vision, olfaction, taste, hearing and touch
Module
Bioinformatics
Credit
5
SDS
BIO/10
Description
Learning Objectives: Provide the students with tools for computational analysis of proteins and genomes. Contents: 1) Sequence alignment methods 2) Methods for studying protein families 3) Protein structure analysis by similarity search 4) Orphan proteins analysis 5) Search for coding regions in sequenced genomes 6) Search for other functional sequences 7) EST and gene expression analysis 8) Databases
