Molecular basis of immunological and neurological diseases
Discipline
Integrated course
Denomination
Molecular basis of immunological and neurological diseases
Modules
2
CFU
10
This teaching course includes the following modules
Module
Clinical immunology
Credit
5
SDS
MED/09
Description
Learning objectives: Learning cellular and molecular mechanisms involved in physiological and pathological immune processes Possible applications of biotechnology. Contents: 1) Macrophages 2) Basophils 3) Mast Cells 4) Chemokines 5) T and B lymphocytes 6) Superantigens 7) Immune Deficiency 8) IgA Deficiency 9) Hypogammaglobulinemia 10) Mastocytosis 11) Eosinophils 12) Food Allergy 13) Bronchial Asthma 14) Urticaria 15) Angioedema 16) Drug Allergy 17) Anaphylaxis 18) Systemic Lupus Erythematosus 19) Reumatoid Arthritis 20) Biologic therapy of Rheumatoid Arthritis 21) Anti-IgE Therapy in Allergic Diseases
Module
Neurology
Credit
5
SDS
MED/26
Description
Learning objectives: To know the tools provided by biotechnology to study the molecular basis of neurological diseases applied to diagnosis and treatment. Contents: 1) Hints of anatomy and physiology of CNS and PNS; CSF and cerebrospinal fluid circulation. 2) Neuron; cytoskeleton; axonal transport; glial cells; myelin; action and resting membrane potential; impulse conduction; synaptic transmission; neurotransmitters; receptors; blood-brain barrier; cerebral metabolism. 3) General information on main neurological syndromes: central and peripheral paralysis; hypokinetic and hyperkinetic extrapyramidal syndromes; cerebellar syndrome; dementia syndromes. 4) Pathogenesis of the main movement disorders: Parkinson's disease, Huntington's disease, Friedreich's ataxia; ataxia from DNA damage repair defect; dominant spinocerebellar ataxias. 5) Pathogenesis of Alzheimer's dementia and frontotemporal dementia; role of amyloid and tau proteins. 6) Impaired copper metabolism diseases: Wilson's disease and Menkes disease. 7) Multiple sclerosis: symptoms and signs, diagnosis and therapy; genetic and environmental pathogenic factors; experimental allergic encephalitis; myelin and axonal damage; humoral and cellular immunity. 8) Dysimmune neuropathies: Guillain-Barré syndrome. 9) Myasthenia gravis. 10) Epilepsy: classification and main clinical basics of seizures; hints of diagnosis and therapy; pathogenesis of seizures; experimental models and human mutations; thalamic-cortical circuits and absence seizures (petit mal). 11) Vascular disease: cerebral circulation; epidemiology and clinical signs of ischemia and cerebral hemorrhage; pathogenesis of cerebral ischemia; genetic causes of cerebral ischemia.